Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 7/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16565843 | 0.85 | OPRM1 (0.50) | SLC6A4SLC6A3OPRK1OPRM1CYP3A4 | |
| SCHEMBL7705762 | 0.84 | SLC6A4 (0.55) | SLC6A4SLC6A3OPRK1CYP3A4ALOX15 | |
| SCHEMBL21078156 | 0.84 | SLC6A4 (0.45) | SLC6A4SLC6A3OPRK1OPRM1OPRD1 | |
| SCHEMBL17886621 | 0.81 | SLC6A4 (0.43) | SLC6A4SLC6A3OPRK1OPRM1OPRD1 | |
| SCHEMBL5962422 | 0.80 | OPRM1 (0.63) | OPRK1OPRM1OPRD1OPRL1TSHR | |
| SCHEMBL19226740 | 0.77 | DRD2 (0.56) | SLC6A4SLC6A3CYP2D6OPRK1CYP3A4 | |
| SCHEMBL19998537 | 0.76 | DRD2 (0.46) | SLC6A4SLC6A3CYP2D6OPRK1OPRM1 | |
| SCHEMBL29964264 | 0.72 | CYP2D6 (0.41) | SLC6A4SLC6A3CYP2D6OPRK1OPRM1 | |
| SCHEMBL20003975 | 0.71 | SLC6A4 (0.48) | SLC6A4SLC6A3CYP2D6OPRK1OPRM1 | |
| SCHEMBL17888193 | 0.70 | OPRM1 (0.49) | SLC6A3OPRK1OPRM1OPRD1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180086757-A1 | TRIAZOLOPYRIDINE COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2018-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180086757-A1 | TRIAZOLOPYRIDINE COMPOUNDS AND METHODS OF USE THEREOF | JAK1, JAK2, JAK3 | SLC6A4 3188/4885SLC6A3 2605/4885CYP2D6 619/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.