Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 20/20 | 0.76 |
| ▸ | KIT | P10721 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL897365 | 0.86 | ALK (1.00) | ALKKITKDR | |
| SCHEMBL896771 | 0.85 | ALK (0.74) | ALKKITKDR | |
| SCHEMBL20004578 | 0.82 | ALK (0.77) | ALKKITKDR | |
| SCHEMBL20366549 | 0.77 | ALK (0.65) | ALKKITKDR | |
| SCHEMBL897165 | 0.75 | ALK (0.62) | ALK | |
| SCHEMBL1703864 | 0.74 | ALK (0.59) | ALKKDR | |
| SCHEMBL20004584 | 0.74 | ALK (0.62) | ALK | |
| SCHEMBL20004694 | 0.73 | ALK (0.53) | ALK | |
| SCHEMBL7808987 | 0.73 | ALK (0.77) | ALKKITKDR | |
| SCHEMBL20004147 | 0.73 | ALK (0.62) | ALKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3613729-A1 | TETRACYCLIC COMPOUNDS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2020-02-26 | — | — | EP | disclosed |
| EP-3345903-B1 | TETRACYCLIC COMPOUNDS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2019-10-09 | — | — | EP | disclosed |
| EP-3345903-A1 | TETRACYCLIC COMPOUNDS | Chugai Seiyaku Kabushiki Kaisha (JP) | 2018-07-11 | — | — | EP | disclosed |
| EP-2975024-B1 | TETRACYCLIC COMPOUNDS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2018-03-28 | — | — | EP | disclosed |