Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 16/20 | 0.77 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL897365 | 0.87 | ALK (1.00) | ALKKITKDR | |
| SCHEMBL1755935 | 0.84 | ALK (0.55) | ALKKITKDR | |
| SCHEMBL1755840 | 0.83 | ALK (0.64) | ALKKITKDR | |
| SCHEMBL7810026 | 0.74 | ALK (0.65) | ALKALDH1A1MAPTMAPK1 | |
| SCHEMBL20004138 | 0.73 | ALK (0.76) | ALKKITKDR | |
| SCHEMBL7805398 | 0.73 | ALK (0.77) | ALKKITKDR | |
| SCHEMBL897235 | 0.72 | ALK (0.82) | ALKKITKDR | |
| SCHEMBL896771 | 0.71 | ALK (0.74) | ALKKITKDR | |
| SCHEMBL24676221 | 0.70 | ALK (0.51) | ALKMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL7812045 | 0.70 | ALK (0.56) | ALKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010143664-A1 | TETRACYCLIC COMPOUND | 中外製薬株式会社 (JP) | 2010-12-16 | — | — | WO | disclosed |