Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 2/20 | 0.74 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.68 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.68 |
| ▸ | CA1 | P00915 | 10/20 | 0.67 |
| ▸ | CA2 | P00918 | 10/20 | 0.67 |
| ▸ | CA12 | O43570 | 6/20 | 0.67 |
| ▸ | CA9 | Q16790 | 6/20 | 0.67 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | CA7 | P43166 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | CA4 | P22748 | 2/20 | 0.58 |
| ▸ | CA6 | P23280 | 1/20 | 0.57 |
| ▸ | CA5A | P35218 | 1/20 | 0.57 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.57 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1998361 | 0.86 | STAT3 (0.78) | STAT3CTDSP1SIRT5CA1CA2 | |
| SCHEMBL24355560 | 0.85 | MEN1 (0.81) | CA1CA2CA12CA9PTPN7 | |
| SCHEMBL1999371 | 0.85 | STAT3 (1.00) | STAT3CTDSP1SIRT5CA1CA2 | |
| SCHEMBL25752409 | 0.84 | STAT3 (0.79) | STAT3CTDSP1SIRT5CA2CA9 | |
| SCHEMBL2002782 | 0.83 | STAT3 (0.69) | STAT3CTDSP1SIRT5CA1CA2 | |
| SCHEMBL4456216 | 0.81 | STAT3 (1.00) | STAT3CTDSP1SIRT5CA1CA2 | |
| SCHEMBL31249645 | 0.81 | STAT3 (1.00) | STAT3CTDSP1SIRT5CA1CA2 | |
| SCHEMBL15517971 | 0.81 | STAT3 (0.62) | STAT3CTDSP1SIRT5CA1CA2 | |
| SCHEMBL7794429 | 0.81 | CA1 (0.69) | CA1CA2CA12CA9CA7 | |
| SCHEMBL25752314 | 0.80 | STAT3 (0.71) | STAT3CTDSP1SIRT5CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210121427-A1 | SMALL MOLECULE INHIBITORS OF STAT3 WITH ANTI-TUMOR ACTIVITY | H LEE MOFFITT CANCER CT & RES (US) | 2021-04-29 | — | — | US | disclosed |
| US-20210121427-A1 | SMALL MOLECULE INHIBITORS OF STAT3 WITH ANTI-TUMOR ACTIVITY | H LEE MOFFITT CANCER CT & RES (US) | 2021-04-29 | — | — | US | disclosed |
| US-10806712-B2 | Small molecule inhibitors of STAT3 with anti-tumor activity | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2020-10-20 | — | — | US | disclosed |
| US-10806712-B2 | Small molecule inhibitors of STAT3 with anti-tumor activity | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2020-10-20 | — | — | US | disclosed |
| US-20190192461-A1 | SMALL MOLECULE INHIBITORS OF STAT3 WITH ANTI-TUMOR ACTIVITY | H LEE MOFFITT CANCER CT & RES (US) | 2019-06-27 | — | — | US | disclosed |
| US-20190192461-A1 | SMALL MOLECULE INHIBITORS OF STAT3 WITH ANTI-TUMOR ACTIVITY | H LEE MOFFITT CANCER CT & RES (US) | 2019-06-27 | — | — | US | disclosed |
| US-10226439-B2 | Small molecule inhibitors of STAT3 with anti-tumor activity | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2019-03-12 | — | — | US | disclosed |
| US-10226439-B2 | Small molecule inhibitors of STAT3 with anti-tumor activity | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2019-03-12 | — | — | US | disclosed |
| US-20170202795-A1 | SMALL MOLECULE INHIBITORS OF STAT3 WITH ANTI-TUMOR ACTIVITY | H LEE MOFFITT CANCER CT & RES (US) | 2017-07-20 | — | — | US | disclosed |
| US-20170202795-A1 | SMALL MOLECULE INHIBITORS OF STAT3 WITH ANTI-TUMOR ACTIVITY | H LEE MOFFITT CANCER CT & RES (US) | 2017-07-20 | — | — | US | disclosed |
| US-9604923-B2 | Small molecule inhibitors of STAT3 with anti-tumor activity | H.LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2017-03-28 | — | — | US | disclosed |
| US-20140329900-A1 | SMALL MOLECULE INHIBITORS OF STAT3 WITH ANTI-TUMOR ACTIVITY | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2014-11-06 | — | — | US | disclosed |
| US-20140329900-A1 | SMALL MOLECULE INHIBITORS OF STAT3 WITH ANTI-TUMOR ACTIVITY | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2014-11-06 | — | — | US | disclosed |
| US-20140329900-A1 | SMALL MOLECULE INHIBITORS OF STAT3 WITH ANTI-TUMOR ACTIVITY | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2014-11-06 | — | — | US | disclosed |
| US-20110201576-A1 | Small molecule inhibitors of stat3 with anti-tumor activity | H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE (US) | 2011-08-18 | — | — | US | disclosed |
| US-20110201576-A1 | Small molecule inhibitors of stat3 with anti-tumor activity | H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE (US) | 2011-08-18 | — | — | US | disclosed |
| US-7960434-B2 | Small molecule inhibitors of STAT3 with anti-tumor activity | UNIVERSITY OF SOUTH FLORIDA (US) | 2011-06-14 | — | — | US | disclosed |
| US-7960434-B2 | Small molecule inhibitors of STAT3 with anti-tumor activity | UNIVERSITY OF SOUTH FLORIDA (US) | 2011-06-14 | — | — | US | disclosed |
| US-20090069420-A1 | Small molecule inhibitors of STAT3 with anti-tumor activity | H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE (US) | 2009-03-12 | — | — | US | disclosed |
| US-20090069420-A1 | Small molecule inhibitors of STAT3 with anti-tumor activity | H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE (US) | 2009-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170202795-A1 | SMALL MOLECULE INHIBITORS OF STAT3 WITH ANTI-TUMOR ACTIVITY | STAT3, STAT1, STAT5A | STAT3 1/4885CTDSP1 489/4885SIRT5 820/4885 |
| US-20210121427-A1 | SMALL MOLECULE INHIBITORS OF STAT3 WITH ANTI-TUMOR ACTIVITY | STAT3, STAT1, STAT5A | STAT3 1/4885CTDSP1 489/4885SIRT5 820/4885 |
| US-20110201576-A1 | Small molecule inhibitors of stat3 with anti-tumor activity | STAT3, STAT1, STAT5A | STAT3 1/4885CTDSP1 489/4885SIRT5 820/4885 |
| US-20090069420-A1 | Small molecule inhibitors of STAT3 with anti-tumor activity | STAT3, STAT1, STAT5A | STAT3 1/4885CTDSP1 489/4885SIRT5 820/4885 |
| US-20140329900-A1 | SMALL MOLECULE INHIBITORS OF STAT3 WITH ANTI-TUMOR ACTIVITY | STAT3, STAT1, JAK2 | STAT3 1/4885CTDSP1 599/4885SIRT5 667/4885 |
| US-20190192461-A1 | SMALL MOLECULE INHIBITORS OF STAT3 WITH ANTI-TUMOR ACTIVITY | STAT3, STAT1, STAT5A | STAT3 1/4885CTDSP1 489/4885SIRT5 820/4885 |
| US-10226439-B2 | Small molecule inhibitors of STAT3 with anti-tumor activity | STAT3, STAT1, STAT5A | STAT3 1/4885CTDSP1 489/4885SIRT5 820/4885 |
| US-10806712-B2 | Small molecule inhibitors of STAT3 with anti-tumor activity | STAT3, STAT1, STAT5A | STAT3 1/4885CTDSP1 489/4885SIRT5 820/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.