Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | PTPRZ1 | P23471 | 1/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.30 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.30 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26962919 | 0.86 | CA1 (0.42) | ALDH1A1KDM4ETDP1CYP3A4GAA | |
| SCHEMBL696891 | 0.83 | ALDH1A1 (0.41) | ALDH1A1KDM4ETDP1CYP3A4CA1 | |
| SCHEMBL699094 | 0.83 | ALDH1A1 (0.41) | ALDH1A1KDM4ETDP1CYP3A4CA1 | |
| SCHEMBL27863787 | 0.81 | ALDH1A1 (0.39) | ALDH1A1KDM4ETDP1CYP3A4KCNH2 | |
| SCHEMBL697758 | 0.79 | ALDH1A1 (0.38) | ALDH1A1CYP3A4CA1CA2CA9 | |
| SCHEMBL698075 | 0.78 | ALDH1A1 (0.37) | ALDH1A1CYP3A4CA1CA2CA9 | |
| SCHEMBL15947450 | 0.78 | ALDH1A1 (0.39) | ALDH1A1KDM4ETDP1CYP3A4GAA | |
| SCHEMBL10804924 | 0.77 | HSD17B10 (0.44) | ALDH1A1KDM4ETDP1CYP3A4KCNH2 | |
| SCHEMBL3628365 | 0.77 | ALDH1A1 (0.52) | ALDH1A1KDM4ETDP1CYP3A4GAA | |
| SCHEMBL30599573 | 0.77 | ALDH1A1 (0.52) | ALDH1A1KDM4ETDP1CYP3A4GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8349865-B2 | Inhibitors of janus kinases | MERCK SHARP & DOHME CORP. (US) | 2013-01-08 | — | — | US | disclosed |
| EP-2200612-B1 | INHIBITORS OF JANUS KINASES | SCHERING CORP (US) | 2012-08-08 | — | — | EP | disclosed |
| US-8084486-B2 | Substituted arylpyrazoles | PFIZER LIMITED (GB) | 2011-12-27 | — | — | US | disclosed |
| US-20110196011-A1 | SUBSTITUTED ARYLPYRAZOLES | PFIZER LIMITED (GB) | 2011-08-11 | — | — | US | disclosed |
| US-7960426-B2 | Substituted arylpyrazoles | PFIZER LIMITED (GB) | 2011-06-14 | — | — | US | disclosed |
| US-7902232-B2 | Substituted arylpyrazoles | PFIZER LIMITED (GB) | 2011-03-08 | — | — | US | disclosed |
| US-7803832-B2 | N-(1-arylpyrazol-4L)sulfonamides and their use as parasiticides | PFIZER INC. (US) | 2010-09-28 | — | — | US | disclosed |
| US-20100197634-A1 | INHIBITORS OF JANUS KINASES | MERCK SHARP & DOHME LLC | 2010-08-05 | — | — | US | disclosed |
| EP-2200612-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-06-30 | — | — | EP | disclosed |
| US-7687533-B2 | N-(1-arylpyrazol-4l) sulfonamides and their use as parasiticides | PFIZER INC. (US) | 2010-03-30 | — | — | US | disclosed |
| US-4771048-A | VETERINARY MEDICINE | BAYER AKTIENGESELLSCHAFT (DE) | 1988-09-13 | — | — | US | disclosed |
| US-4766144-A | 3-carbamoyl-4-hydroxy-coumarins for combating parasitic heiminths | BAYER AKTIENGESELLSCHAFT (DE) | 1988-08-23 | — | — | US | disclosed |
| US-4734122-A | Substituted 5-acylamino-1-phenylpyrazoles composition containing them, and herbicidal method of using them | BAYER AKTIENGESELLSCHAFT (DE) | 1988-03-29 | — | — | US | disclosed |
| EP-0241834-A2 | Use of 3-carbamoyl-4-hydroxy-cumarines in combating parasiticidal helminths, 3-carbamoyl-4-hydroxy-cumarines and their preparation | BAYER AG (DE) | 1987-10-21 | — | — | EP | disclosed |
| EP-0234119-A1 | Pesticidal method using N-phenylpyrazoles | RHONE-POULENC AGROCHIMIE (FR) | 1987-09-02 | — | — | EP | disclosed |
| EP-0231512-A1 | Cyclic malonylphosphonic acid diamides, process for their preparation and their use for pestcontrol | BAYER AG (DE) | 1987-08-12 | — | — | EP | disclosed |
| WO-1987003781-A1 | PESTICIDAL METHOD USING N-PHENYLPYRAZOLES | MAY & BAKER LIMITED (GB) | 1987-07-02 | — | — | WO | disclosed |
| US-4668280-A | Herbicidally active substituted 5-acylamino-1-phenylpyrazoles | BAYER AKTIENGESELLSCHAFT (DE) | 1987-05-26 | — | — | US | disclosed |
| EP-0171544-A1 | Substituted 5-acylamino-1-phenylpyrazoles | BAYER AG (DE) | 1986-02-19 | — | — | EP | disclosed |
| EP-0138149-A2 | 5-Acylamino-1-phenyl pyrazoles | BAYER AG (DE) | 1985-04-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197634-A1 | INHIBITORS OF JANUS KINASES | JAK2, JAK3, JAK1 | ALDH1A1 3244/4885KDM4E 653/4885TDP1 1401/4885 |
| US-20110196011-A1 | SUBSTITUTED ARYLPYRAZOLES | CYP4X1, EPX, CYP2C9 | ALDH1A1 963/4885KDM4E 966/4885TDP1 3276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.