Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 7/20 | 0.35 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.33 |
| ▸ | CFB | P00751 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.33 |
| ▸ | EML4 | Q9HC35 | 2/20 | 0.33 |
| ▸ | SRPK2 | P78362 | 2/20 | 0.32 |
| ▸ | SRPK1 | Q96SB4 | 2/20 | 0.32 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.32 |
| ▸ | GABRP | O00591 | 1/20 | 0.32 |
| ▸ | GABRD | O14764 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28588337 | 0.75 | PIN1 (0.45) | ALKPIN1MEN1KMT2AEML4 | |
| SCHEMBL24676285 | 0.70 | ALK (0.42) | ALKMEN1KMT2A | |
| SCHEMBL20004106 | 0.68 | ALK (0.51) | ALK | |
| SCHEMBL21443144 | 0.68 | ALK (0.38) | ALKEML4SRPK2SRPK1SERPINE1 | |
| SCHEMBL21443123 | 0.68 | ALK (0.37) | ALKEML4SRPK2SRPK1 | |
| SCHEMBL20004742 | 0.65 | ALK (0.42) | ALKEML4SRPK2SRPK1 | |
| SCHEMBL24195300 | 0.65 | TDP1 (0.62) | MEN1KMT2AGABRPGABRDGABRA1 | |
| SCHEMBL897916 | 0.65 | PIN1 (0.38) | GSK3BALKPIN1CFB | |
| SCHEMBL24676771 | 0.65 | SLC22A12 (0.46) | MEN1KMT2A | |
| SCHEMBL31554152 | 0.64 | POLB (0.47) | KMT2AGABRPGABRDGABRA1GABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2975024-B1 | TETRACYCLIC COMPOUNDS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2018-03-28 | — | — | EP | disclosed |