Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 11/20 | 0.46 |
| ▸ | TTR | P02766 | 4/20 | 0.43 |
| ▸ | EYA3 | Q99504 | 6/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | PGR | P06401 | 2/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20366740 | 0.71 | ALK (0.41) | SLC22A12TTREYA3CYP3A4MAPT | |
| SCHEMBL1287582 | 0.68 | EYA3 (0.71) | SLC22A12TTREYA3CYP2C19CYP2C9 | |
| SCHEMBL20004875 | 0.65 | GSK3B (0.35) | MEN1KMT2A | |
| SCHEMBL1287413 | 0.64 | SLC22A12 (1.00) | SLC22A12TTREYA3CYP2C19CYP2C9 | |
| SCHEMBL28104862 | 0.64 | EYA3 (0.57) | SLC22A12TTREYA3CYP2C19CYP2C9 | |
| SCHEMBL29286599 | 0.63 | EYA3 (0.70) | SLC22A12TTREYA3CYP2C19CYP2C9 | |
| SCHEMBL6338104 | 0.62 | EYA3 (0.70) | SLC22A12TTREYA3CYP2C19CYP2C9 | |
| SCHEMBL28104498 | 0.62 | EYA3 (0.64) | SLC22A12TTREYA3CYP2C19CYP2C9 | |
| SCHEMBL7449274 | 0.61 | HSD17B3 (0.44) | ALDH1A1 | |
| SCHEMBL9444753 | 0.61 | EYA3 (0.68) | SLC22A12TTREYA3CYP2C19CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230142119-A1 | TETRACYCLIC COMPOUND | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2023-05-11 | — | — | US | disclosed |
| US-20220306578-A1 | TETRACYCLIC COMPOUND | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2022-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230142119-A1 | TETRACYCLIC COMPOUND | ALK, TTR, ACVR1 | SLC22A12 1472/4885TTR 2/4885EYA3 1232/4885 |
| US-20220306578-A1 | TETRACYCLIC COMPOUND | ALK, TTR, ACVR1 | SLC22A12 1472/4885TTR 2/4885EYA3 1232/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.