SCHEMBL20005209

SCHEMBL20005209

CCCOc1ccc(C#Cc2c(C)cc(-c3ccc(-c4ccc(C)cc4F)cc3)cc2F)cc1

nearest known ligand 0.36

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MCHR1 Q99705 2/20 0.36
ACACB O00763 10/20 0.36
ACACA Q13085 1/20 0.35
CHRM1 P11229 1/20 0.35
HTR2A P28223 1/20 0.35
RARA P10276 1/20 0.35
RARB P10826 1/20 0.35
GRM5 P41594 1/20 0.35
PTGS1 P23219 1/20 0.34
PTGS2 P35354 1/20 0.34
MAPT P10636 2/20 0.33
ALDH1A1 P00352 1/20 0.33
GAA P10253 1/20 0.33
MAPK1 P28482 1/20 0.33
MAOB P27338 1/20 0.33
KDM1A O60341 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20005270 0.94 ACACB (0.35) MCHR1ACACBACACACHRM1HTR2A
SCHEMBL20004622 0.91 MCHR1 (0.40) MCHR1ACACBCHRM1HTR2ARARA
SCHEMBL20005219 0.88 HMOX1 (0.38) MCHR1ACACBACACACHRM1HTR2A
SCHEMBL19999489 0.87 ACACB (0.40) MCHR1ACACBACACACHRM1HTR2A
SCHEMBL20004766 0.87 MAPT (0.39) MCHR1ACACBCHRM1HTR2ARARA
SCHEMBL19999622 0.85 RARA (0.38) MCHR1ACACBACACACHRM1HTR2A
SCHEMBL19999621 0.85 ACACB (0.39) MCHR1ACACBACACACHRM1HTR2A
SCHEMBL20004905 0.84 ESR1 (0.34) GRM5KDM1A
SCHEMBL20004824 0.84 KDM1A (0.35) GRM5KDM1A
SCHEMBL22600463 0.83 GRM5 (0.44) ACACBACACARARARARBGRM5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3299439-A1 LIQUID CRYSTAL COMPOUND, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC Corporation (JP) 2018-03-28 EP disclosed