SCHEMBL20005276

SCHEMBL20005276

Cc1ccc(CCc2cc(C)c(C#Cc3ccc(-c4ccc(C)cc4)cc3)c(F)c2)cc1

nearest known ligand 0.42

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 13/20 0.42
PTGS1 P23219 1/20 0.39
PTGS2 P35354 1/20 0.39
CYP1A2 P05177 1/20 0.35
CYP2A6 P11509 1/20 0.35
TAAR1 Q96RJ0 1/20 0.35
CYP17A1 P05093 1/20 0.33
CYP21A2 P08686 1/20 0.33
CYP11B1 P15538 1/20 0.33
TSHR P16473 1/20 0.33
HSD17B10 Q99714 1/20 0.33
ACACB O00763 2/20 0.33
KCNH2 Q12809 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20005274 0.93 TSHR (0.43) FFAR1PTGS1PTGS2TSHRHSD17B10
SCHEMBL19999462 0.86 TSHR (0.44) FFAR1PTGS1PTGS2TSHRHSD17B10
SCHEMBL20006853 0.85 FFAR1 (0.40) FFAR1CYP1A2CYP2A6TAAR1TSHR
SCHEMBL19403026 0.85 GRM5 (0.37) FFAR1PTGS1PTGS2CYP1A2CYP2A6
SCHEMBL20005208 0.85 HRH3 (0.38) FFAR1TSHRHSD17B10
SCHEMBL19999384 0.84 TSHR (0.51) FFAR1TSHRHSD17B10
SCHEMBL20004483 0.83 TSHR (0.44) FFAR1TSHRHSD17B10
SCHEMBL20004744 0.83 TSHR (0.46) FFAR1TSHRHSD17B10
SCHEMBL19999463 0.82 TSHR (0.49) FFAR1TSHRHSD17B10
SCHEMBL20005221 0.82 GRM5 (0.37) FFAR1PTGS2CYP1A2CYP2A6CYP11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3299439-A1 LIQUID CRYSTAL COMPOUND, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC Corporation (JP) 2018-03-28 EP disclosed