Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 10/20 | 0.72 |
| ▸ | MEN1 | O00255 | 9/20 | 0.72 |
| ▸ | POLB | P06746 | 4/20 | 0.72 |
| ▸ | CRHBP | P24387 | 2/20 | 0.72 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.72 |
| ▸ | MAPT | P10636 | 12/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.62 |
| ▸ | GAA | P10253 | 4/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | NPC1 | O15118 | 2/20 | 0.62 |
| ▸ | MITF | O75030 | 1/20 | 0.62 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.62 |
| ▸ | NSD2 | O96028 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.59 |
| ▸ | HTT | P42858 | 4/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.59 |
| ▸ | RECQL | P46063 | 2/20 | 0.59 |
| ▸ | JAK2 | O60674 | 1/20 | 0.59 |
| ▸ | NPY2R | P49146 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18102931 | 1.00 | KMT2A (0.72) | KMT2AMEN1POLBCRHBPCRHR2 | |
| SCHEMBL18103080 | 0.77 | MAPT (0.75) | KMT2AMEN1POLBCRHBPCRHR2 | |
| SCHEMBL20005699 | 0.77 | MAPT (0.75) | KMT2AMEN1POLBCRHBPCRHR2 | |
| SCHEMBL18102995 | 0.77 | KMT2A (0.70) | KMT2AMEN1POLBCRHBPCRHR2 | |
| SCHEMBL12008472 | 0.77 | MAPT (1.00) | KMT2AMEN1CRHBPCRHR2MAPT | |
| SCHEMBL12008473 | 0.75 | MAPT (0.88) | KMT2AMEN1CRHBPCRHR2MAPT | |
| SCHEMBL20846973 | 0.74 | MAPT (1.00) | KMT2AMEN1POLBMAPTTDP1 | |
| SCHEMBL18103040 | 0.74 | MEN1 (0.67) | KMT2AMEN1POLBCRHBPCRHR2 | |
| SCHEMBL19999093 | 0.74 | MAPT (0.70) | KMT2AMEN1POLBMAPTTDP1 | |
| SCHEMBL21586136 | 0.74 | MAPT (0.70) | KMT2AMEN1POLBMAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10501413-B2 | Inhibitors of the Notch transcriptional activation complex and methods for use of the same | UNIVERSITY OF MIAMI (US) | 2019-12-10 | — | — | US | disclosed |
| US-20180086700-A1 | INHIBITORS OF THE NOTCH TRANSCRIPTIONAL ACTIVATION COMPLEX AND METHODS FOR USE OF THE SAME | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10501413-B2 | Inhibitors of the Notch transcriptional activation complex and methods for use of the same | NOTCH1, CBFB, HES1 | KMT2A 470/4885MEN1 846/4885POLB 1009/4885 |
| US-20180086700-A1 | INHIBITORS OF THE NOTCH TRANSCRIPTIONAL ACTIVATION COMPLEX AND METHODS FOR USE OF THE SAME | NOTCH1, CBFB, HES1 | KMT2A 470/4885MEN1 846/4885POLB 1009/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.