Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.72 |
| ▸ | CTRC | Q99895 | 1/20 | 0.63 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.61 |
| ▸ | MYC | P01106 | 1/20 | 0.60 |
| ▸ | MAX | P61244 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | MITF | O75030 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | PTPN7 | P35236 | 3/20 | 0.56 |
| ▸ | PTPN12 | Q05209 | 3/20 | 0.56 |
| ▸ | GPR35 | Q9HC97 | 3/20 | 0.56 |
| ▸ | PTPN22 | Q9Y2R2 | 3/20 | 0.56 |
| ▸ | DDX3X | O00571 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | CFTR | P13569 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18103053 | 1.00 | MAPK1 (0.72) | MAPK1CTRCHSD17B3MYCMAX | |
| SCHEMBL7852521 | 0.86 | MAPK1 (0.76) | MAPK1KMT2AMITFMEN1CTDSP1 | |
| SCHEMBL4138637 | 0.84 | MAPK1 (0.72) | MAPK1KMT2AMITFMEN1CTDSP1 | |
| SCHEMBL4138638 | 0.84 | MAPK1 (0.72) | MAPK1KMT2AMITFMEN1CTDSP1 | |
| SCHEMBL1904246 | 0.83 | MAPK1 (0.71) | MAPK1KMT2AMEN1CTDSP1POLB | |
| SCHEMBL1904243 | 0.83 | MAPK1 (0.71) | MAPK1KMT2AMEN1CTDSP1POLB | |
| SCHEMBL1904245 | 0.83 | MAPK1 (0.71) | MAPK1KMT2AMEN1CTDSP1POLB | |
| SCHEMBL12912717 | 0.83 | CFTR (0.66) | MAPK1CTRCKMT2AMITFMEN1 | |
| SCHEMBL6886476 | 0.81 | MAPK1 (0.75) | MAPK1KMT2AMITFMEN1CTDSP1 | |
| SCHEMBL6886480 | 0.81 | MAPK1 (0.75) | MAPK1KMT2AMITFMEN1CTDSP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10501413-B2 | Inhibitors of the Notch transcriptional activation complex and methods for use of the same | UNIVERSITY OF MIAMI (US) | 2019-12-10 | — | — | US | disclosed |
| US-20180086700-A1 | INHIBITORS OF THE NOTCH TRANSCRIPTIONAL ACTIVATION COMPLEX AND METHODS FOR USE OF THE SAME | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10501413-B2 | Inhibitors of the Notch transcriptional activation complex and methods for use of the same | NOTCH1, CBFB, HES1 | MAPK1 2158/4885CTRC 3530/4885HSD17B3 2572/4885 |
| US-20180086700-A1 | INHIBITORS OF THE NOTCH TRANSCRIPTIONAL ACTIVATION COMPLEX AND METHODS FOR USE OF THE SAME | NOTCH1, CBFB, HES1 | MAPK1 2158/4885CTRC 3530/4885HSD17B3 2572/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.