Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.73 |
| ▸ | MEN1 | O00255 | 2/20 | 0.73 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.73 |
| ▸ | POLB | P06746 | 1/20 | 0.73 |
| ▸ | BLM | P54132 | 1/20 | 0.73 |
| ▸ | DDX3X | O00571 | 2/20 | 0.71 |
| ▸ | MAPT | P10636 | 4/20 | 0.68 |
| ▸ | PTPN7 | P35236 | 3/20 | 0.68 |
| ▸ | PTPN12 | Q05209 | 3/20 | 0.68 |
| ▸ | GPR35 | Q9HC97 | 3/20 | 0.68 |
| ▸ | PTPN22 | Q9Y2R2 | 3/20 | 0.68 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.68 |
| ▸ | MMP2 | P08253 | 1/20 | 0.68 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.68 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.65 |
| ▸ | MAOA | P21397 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | NCOA3 | Q9Y6Q9 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6886476 | 1.00 | MAPK1 (0.75) | MAPK1KMT2AMEN1CTDSP1POLB | |
| SCHEMBL12008556 | 0.94 | PTPN7 (0.74) | MAPK1KMT2AMEN1CTDSP1POLB | |
| SCHEMBL12008759 | 0.94 | MAPK1 (0.66) | MAPK1KMT2AMEN1CTDSP1POLB | |
| SCHEMBL1904245 | 0.89 | MAPK1 (0.71) | MAPK1KMT2AMEN1CTDSP1POLB | |
| SCHEMBL1904246 | 0.89 | MAPK1 (0.71) | MAPK1KMT2AMEN1CTDSP1POLB | |
| SCHEMBL1904243 | 0.89 | MAPK1 (0.71) | MAPK1KMT2AMEN1CTDSP1POLB | |
| SCHEMBL6888301 | 0.88 | MAPK1 (0.63) | MAPK1KMT2AMEN1CTDSP1POLB | |
| SCHEMBL6720199 | 0.87 | MEN1 (0.85) | MAPK1KMT2AMEN1CTDSP1POLB | |
| SCHEMBL30034885 | 0.85 | PTPN7 (0.66) | MAPK1KMT2AMEN1CTDSP1POLB | |
| SCHEMBL12008593 | 0.85 | KMT2A (1.00) | KMT2AMEN1CTDSP1POLBBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6673816-B1 | Rhodanine carboxylic acid derivatives for the treatment and prevention of metabolic bone disorders | Esswein, Angelika (DE) | 2004-01-06 | — | — | US | disclosed |
| US-20030032813-A1 | Rhodanine carboxylic acid derivatives for the treatment and prevention of metabolic bone disorders | ANGELIKA ESSWEIN, WOLFGANG SCHAEFER, AND KONRAD HONOLD | 2003-02-13 | — | — | US | disclosed |
| EP-1117655-A1 | RHODANINE CARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT AND PREVENTION OF METABOLIC BONE DISORDERS | Esswein, Angelika (DE) | 2001-07-25 | — | — | EP | disclosed |
| WO-2000018747-A1 | RHODANINE CARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT AND PREVENTION OF METABOLIC BONE DISORDERS | ROCHE DIAGNOSTICS GMBH (DE) | 2000-04-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030032813-A1 | Rhodanine carboxylic acid derivatives for the treatment and prevention of metabolic bone disorders | NR1H4, NR1D1, NR1I2 | MAPK1 1107/4885KMT2A 1995/4885MEN1 838/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.