Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | BLM | P54132 | 1/20 | 0.65 |
| ▸ | PTPN12 | Q05209 | 4/20 | 0.63 |
| ▸ | PTPN22 | Q9Y2R2 | 4/20 | 0.63 |
| ▸ | PTPN7 | P35236 | 3/20 | 0.62 |
| ▸ | GPR35 | Q9HC97 | 3/20 | 0.62 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.62 |
| ▸ | MMP2 | P08253 | 1/20 | 0.62 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.62 |
| ▸ | DDX3X | O00571 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.58 |
| ▸ | MMP3 | P08254 | 2/20 | 0.58 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.58 |
| ▸ | MMP13 | P45452 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1904246 | 1.00 | MAPK1 (0.71) | MAPK1KMT2AMEN1CTDSP1POLB | |
| SCHEMBL1904245 | 1.00 | MAPK1 (0.71) | MAPK1KMT2AMEN1CTDSP1POLB | |
| SCHEMBL6886476 | 0.89 | MAPK1 (0.75) | MAPK1KMT2AMEN1CTDSP1POLB | |
| SCHEMBL6886480 | 0.89 | MAPK1 (0.75) | MAPK1KMT2AMEN1CTDSP1POLB | |
| SCHEMBL8208103 | 0.89 | MITF (0.69) | MAPK1KMT2AAKR1B1 | |
| SCHEMBL8208084 | 0.89 | MITF (0.69) | MAPK1KMT2AAKR1B1 | |
| SCHEMBL12008556 | 0.87 | PTPN7 (0.74) | MAPK1KMT2AMEN1CTDSP1POLB | |
| SCHEMBL19425577 | 0.86 | MAPK1 (0.55) | MAPK1KMT2AMEN1CTDSP1POLB | |
| SCHEMBL6886024 | 0.86 | AKR1B1 (0.70) | KMT2AMEN1POLBPSMD14AKR1B1 | |
| SCHEMBL6886020 | 0.86 | AKR1B1 (0.70) | KMT2AMEN1POLBPSMD14AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7947717-B2 | Inhibitors of lethal factor protease | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2011-05-24 | — | — | US | disclosed |
| US-20100016292-A1 | INHIBITORS OF LETHAL FACTOR PROTEASE | THE BURNHAM INSTITUTE (US) | 2010-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100016292-A1 | INHIBITORS OF LETHAL FACTOR PROTEASE | APAF1, F11, SERPINB1 | MAPK1 2525/4885KMT2A 3345/4885MEN1 1839/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.