Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.80 |
| ▸ | MEN1 | O00255 | 1/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.80 |
| ▸ | LMNA | P02545 | 1/20 | 0.80 |
| ▸ | POLB | P06746 | 1/20 | 0.80 |
| ▸ | GAA | P10253 | 1/20 | 0.80 |
| ▸ | MAPT | P10636 | 1/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.80 |
| ▸ | NAT1 | P18440 | 5/20 | 0.64 |
| ▸ | CISD1 | Q9NZ45 | 3/20 | 0.60 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.60 |
| ▸ | MYC | P01106 | 2/20 | 0.56 |
| ▸ | MAX | P61244 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.55 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.55 |
| ▸ | PIM1 | P11309 | 2/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.53 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.53 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8310306 | 0.89 | MEN1 (1.00) | NPC1MEN1ALDH1A1LMNAPOLB | |
| SCHEMBL8308378 | 0.89 | MEN1 (1.00) | NPC1MEN1ALDH1A1LMNAPOLB | |
| SCHEMBL18102959 | 0.88 | MEN1 (0.73) | NPC1MEN1ALDH1A1LMNAPOLB | |
| SCHEMBL8535412 | 0.81 | PTGS2 (0.85) | NPC1MEN1ALDH1A1LMNAPOLB | |
| SCHEMBL17464816 | 0.81 | CISD1 (0.85) | NPC1MEN1ALDH1A1LMNAPOLB | |
| SCHEMBL8535410 | 0.81 | PTGS2 (0.85) | NPC1MEN1ALDH1A1LMNAPOLB | |
| SCHEMBL29376987 | 0.81 | MYC (0.73) | NPC1MEN1ALDH1A1LMNAPOLB | |
| SCHEMBL22492974 | 0.81 | MYC (0.73) | NPC1MEN1ALDH1A1LMNAPOLB | |
| SCHEMBL22492973 | 0.81 | MYC (0.73) | NPC1MEN1ALDH1A1LMNAPOLB | |
| SCHEMBL8536887 | 0.79 | NPC1 (0.61) | NPC1MEN1ALDH1A1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10501413-B2 | Inhibitors of the Notch transcriptional activation complex and methods for use of the same | UNIVERSITY OF MIAMI (US) | 2019-12-10 | — | — | US | disclosed |
| US-20180086700-A1 | INHIBITORS OF THE NOTCH TRANSCRIPTIONAL ACTIVATION COMPLEX AND METHODS FOR USE OF THE SAME | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10501413-B2 | Inhibitors of the Notch transcriptional activation complex and methods for use of the same | NOTCH1, CBFB, HES1 | NPC1 1617/4885MEN1 846/4885ALDH1A1 2177/4885 |
| US-20180086700-A1 | INHIBITORS OF THE NOTCH TRANSCRIPTIONAL ACTIVATION COMPLEX AND METHODS FOR USE OF THE SAME | NOTCH1, CBFB, HES1 | NPC1 1617/4885MEN1 846/4885ALDH1A1 2177/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.