Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.38 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.38 |
| ▸ | GABRE | P78334 | 1/20 | 0.38 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.38 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.38 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.38 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.38 |
| ▸ | GBA1 | P04062 | 1/20 | 0.36 |
| ▸ | LSS | P48449 | 2/20 | 0.36 |
| ▸ | PPIA | P62937 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22732689 | 0.91 | GABRA5 (0.44) | KDM4EGABRA5GABRPGABRDGABRA1 | |
| SCHEMBL10154541 | 0.80 | GABRA5 (0.42) | KDM4EGABRA5GABRPGABRDGABRA1 | |
| SCHEMBL3104534 | 0.80 | KDM4E (0.44) | KDM4EGABRA5GABRPGABRDGABRA1 | |
| SCHEMBL16498201 | 0.79 | KDM4E (0.39) | KDM4EGABRA5GBA1LSS | |
| SCHEMBL3994090 | 0.79 | CYP3A4 (0.49) | KDM4EGABRA5GABRPGABRDGABRA1 | |
| SCHEMBL456392 | 0.78 | KDM4E (0.46) | KDM4EGABRA5GABRPGABRDGABRA1 | |
| SCHEMBL7882592 | 0.77 | CYP3A4 (0.51) | KDM4EGABRA5GBA1LSSCYP3A4 | |
| SCHEMBL9699977 | 0.77 | CYP3A4 (0.51) | KDM4EGABRA5GBA1LSSCYP3A4 | |
| SCHEMBL7079305 | 0.77 | CYP3A4 (0.51) | KDM4EGABRA5GBA1LSSCYP3A4 | |
| SCHEMBL7332235 | 0.77 | CYP3A4 (0.51) | KDM4EGABRA5GBA1LSSCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3140303-B1 | IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2018-03-28 | — | — | EP | disclosed |