Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRACR2A | Q9BSW2 | 15/20 | 0.61 |
| ▸ | ORAI1 | Q96D31 | 4/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20006257 | 0.82 | CRACR2A (0.64) | CRACR2AORAI1 | |
| SCHEMBL20006307 | 0.82 | CRACR2A (0.66) | CRACR2AORAI1 | |
| SCHEMBL1667944 | 0.82 | CRACR2A (0.56) | CRACR2AORAI1PTGS2 | |
| SCHEMBL1880912 | 0.82 | CRACR2A (0.56) | CRACR2AORAI1PTGS1PTGS2 | |
| SCHEMBL626659 | 0.82 | CRACR2A (0.56) | CRACR2AORAI1PTGS1PTGS2 | |
| SCHEMBL20006304 | 0.81 | CRACR2A (0.53) | CRACR2AORAI1PTGS1PTGS2 | |
| SCHEMBL30096524 | 0.81 | ORAI1 (0.71) | CRACR2AORAI1 | |
| SCHEMBL20006441 | 0.80 | CRACR2A (0.58) | CRACR2AORAI1 | |
| SCHEMBL20080531 | 0.80 | CRACR2A (0.60) | CRACR2A | |
| SCHEMBL28236668 | 0.79 | PTGS2 (0.56) | ORAI1PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2509955-B1 | PYRAZOLE DERIVATIVES AS MODULATORS OF CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL | RHIZEN PHARMACEUTICALS S A (CH) | 2018-04-25 | — | — | EP | disclosed |
| EP-2509974-B1 | PYRAZOLES DERIVATIVES MODULATORS OF CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL AND METHODS FOR TREATMENT OF NON-SMALL CELL LUNG CANCER | RHIZEN PHARMACEUTICALS S A (CH) | 2018-04-11 | — | — | EP | disclosed |
| EP-3299361-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL | Rhizen Pharmaceuticals S.A. (CH) | 2018-03-28 | — | — | EP | disclosed |