Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRACR2A | Q9BSW2 | 15/20 | 0.51 |
| ▸ | ORAI1 | Q96D31 | 4/20 | 0.41 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.35 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20006441 | 0.80 | CRACR2A (0.58) | CRACR2AORAI1KCNJ6KCNJ3 | |
| SCHEMBL20006247 | 0.77 | CRACR2A (0.55) | CRACR2AORAI1KCNJ6KCNJ3 | |
| SCHEMBL1668597 | 0.72 | CRACR2A (0.52) | CRACR2AORAI1 | |
| SCHEMBL1881601 | 0.68 | CRACR2A (1.00) | CRACR2AORAI1KCNJ6KCNJ3 | |
| SCHEMBL20006573 | 0.68 | CRACR2A (0.59) | CRACR2A | |
| SCHEMBL1668809 | 0.67 | MAPT (0.51) | CRACR2AORAI1 | |
| SCHEMBL20006241 | 0.67 | CRACR2A (0.64) | CRACR2AORAI1 | |
| SCHEMBL12637818 | 0.66 | CRACR2A (0.73) | CRACR2AORAI1 | |
| SCHEMBL13105766 | 0.65 | RAD52 (0.38) | — | |
| SCHEMBL6889813 | 0.64 | CRACR2A (0.61) | CRACR2AORAI1KCNJ6KCNJ3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299361-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL | Rhizen Pharmaceuticals S.A. (CH) | 2018-03-28 | — | — | EP | disclosed |