Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRACR2A | Q9BSW2 | 11/20 | 0.55 |
| ▸ | ORAI1 | Q96D31 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KCNJ6 | P48051 | 4/20 | 0.41 |
| ▸ | KCNJ3 | P48549 | 4/20 | 0.41 |
| ▸ | KCNJ5 | P48544 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20006441 | 0.96 | CRACR2A (0.58) | CRACR2AORAI1KCNJ6KCNJ3 | |
| SCHEMBL20006573 | 0.77 | CRACR2A (0.59) | CRACR2A | |
| SCHEMBL20006524 | 0.77 | CRACR2A (0.51) | CRACR2AORAI1KCNJ6KCNJ3 | |
| SCHEMBL20006306 | 0.77 | CRACR2A (0.61) | CRACR2AORAI1 | |
| SCHEMBL1668597 | 0.76 | CRACR2A (0.52) | CRACR2AORAI1NPC1LMNATP53 | |
| SCHEMBL20006241 | 0.76 | CRACR2A (0.64) | CRACR2AORAI1 | |
| SCHEMBL1879356 | 0.73 | CRACR2A (0.72) | CRACR2AORAI1LMNASMN1; SMN2 | |
| SCHEMBL6889813 | 0.73 | CRACR2A (0.61) | CRACR2AORAI1KCNJ6KCNJ3 | |
| SCHEMBL1667966 | 0.72 | CRACR2A (0.81) | CRACR2AORAI1KCNJ6KCNJ3 | |
| SCHEMBL1666818 | 0.72 | CRACR2A (0.58) | CRACR2AORAI1LMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299361-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL | Rhizen Pharmaceuticals S.A. (CH) | 2018-03-28 | — | — | EP | disclosed |