Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | NPC1 | O15118 | 5/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | IDH1 | O75874 | 4/20 | 0.38 |
| ▸ | IDH2 | P48735 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29402753 | 0.80 | PRMT6 (0.44) | MAPTNPC1RAB9ANPSR1HTT | |
| SCHEMBL6179075 | 0.80 | PRMT6 (0.44) | MAPTNPC1RAB9ANPSR1HTT | |
| SCHEMBL12969074 | 0.78 | NPC1 (0.59) | MAPTNPC1RAB9ANPSR1HTT | |
| SCHEMBL30492741 | 0.77 | PRMT6 (0.44) | MAPTNPC1RAB9ANPSR1HTT | |
| SCHEMBL10162249 | 0.77 | IDH1 (0.40) | MAPTNPC1RAB9ANPSR1HTT | |
| SCHEMBL20392745 | 0.77 | IDH1 (0.40) | MAPTNPC1RAB9APRMT6IDH1 | |
| SCHEMBL28535799 | 0.75 | GCGR (0.45) | MAPTKDM4EGAA | |
| SCHEMBL16180341 | 0.73 | KCNJ1 (0.49) | MAPTNPC1RAB9ANPSR1HTT | |
| SCHEMBL8171100 | 0.73 | TRPV4 (0.52) | — | |
| SCHEMBL10130925 | 0.73 | IDH1 (0.38) | MAPTNPC1RAB9APRMT6IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299361-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL | Rhizen Pharmaceuticals S.A. (CH) | 2018-03-28 | — | — | EP | disclosed |