Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 16/20 | 0.42 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.33 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23614041 | 0.89 | TRPV4 (0.41) | TRPV4TRPC3TRPC6ACACB | |
| SCHEMBL23613934 | 0.88 | TRPV4 (0.37) | TRPV4ACACB | |
| SCHEMBL23613876 | 0.85 | TRPV4 (0.33) | TRPV4ACACB | |
| SCHEMBL23614073 | 0.83 | TRPV4 (0.32) | TRPV4 | |
| SCHEMBL23613864 | 0.81 | ACACB (0.34) | TRPV4ACACB | |
| SCHEMBL23613994 | 0.79 | TRPV4 (0.42) | TRPV4TRPC3TRPC6ACACB | |
| SCHEMBL20007555 | 0.78 | TRPV4 (0.48) | TRPV4ACACB | |
| SCHEMBL20007648 | 0.77 | TRPV4 (0.64) | TRPV4 | |
| SCHEMBL22344219 | 0.76 | TRPV4 (0.63) | TRPV4 | |
| SCHEMBL21172216 | 0.76 | TRPV4 (0.63) | TRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3515887-B1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2021-07-07 | — | — | EP | disclosed |
| WO-2018055524-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2018-03-29 | — | — | WO | disclosed |