Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 17/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23614085 | 0.88 | TRPV4 (0.46) | TRPV4CYP3A4KCNH2 | |
| SCHEMBL20007648 | 0.85 | TRPV4 (0.64) | TRPV4CYP3A4KCNH2 | |
| SCHEMBL23614039 | 0.84 | TRPV4 (0.56) | TRPV4CYP3A4KCNH2AR | |
| SCHEMBL23613855 | 0.83 | TRPV4 (0.57) | TRPV4CYP3A4KCNH2 | |
| SCHEMBL23613949 | 0.78 | TRPV4 (0.55) | TRPV4 | |
| SCHEMBL20007251 | 0.78 | TRPV4 (0.42) | TRPV4ACACB | |
| SCHEMBL30266693 | 0.78 | TRPV4 (0.75) | TRPV4CYP3A4KCNH2 | |
| SCHEMBL20007554 | 0.78 | TRPV4 (0.75) | TRPV4CYP3A4KCNH2 | |
| SCHEMBL20007712 | 0.77 | TRPV4 (0.42) | TRPV4CYP3A4KCNH2 | |
| SCHEMBL23613988 | 0.77 | TRPV4 (0.43) | TRPV4CYP3A4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3515887-B1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2021-07-07 | — | — | EP | disclosed |
| WO-2018055524-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2018-03-29 | — | — | WO | disclosed |