Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 5/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 6/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.32 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20007714 | 0.87 | TRPV4 (0.35) | TRPV4CYP3A4KCNH2 | |
| SCHEMBL20007305 | 0.85 | TRPV4 (0.34) | TRPV4CYP3A4KCNH2 | |
| SCHEMBL20007266 | 0.81 | TRPV4 (0.48) | TRPV4CYP3A4KCNH2 | |
| SCHEMBL23613864 | 0.79 | ACACB (0.34) | TRPV4 | |
| SCHEMBL23614022 | 0.73 | TRPV4 (0.43) | TRPV4CYP3A4KCNH2S1PR3 | |
| SCHEMBL20007809 | 0.70 | TRPV4 (0.42) | TRPV4CYP3A4KCNH2S1PR3 | |
| SCHEMBL23613977 | 0.69 | TRPV4 (0.49) | TRPV4CYP3A4KCNH2 | |
| SCHEMBL20007784 | 0.69 | TRPV4 (0.38) | TRPV4CYP3A4KCNH2 | |
| SCHEMBL20007702 | 0.69 | TRPV4 (0.54) | TRPV4CYP3A4KCNH2S1PR3 | |
| SCHEMBL19995355 | 0.68 | TRPV4 (0.51) | TRPV4CYP3A4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3515887-B1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2021-07-07 | — | — | EP | disclosed |
| WO-2018055524-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2018-03-29 | — | — | WO | disclosed |