Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 19/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | PDE9A | O76083 | 1/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20007574 | 0.73 | TRPV4 (0.55) | TRPV4KCNH2CYP3A4TRPM8 | |
| SCHEMBL20007712 | 0.71 | TRPV4 (0.42) | TRPV4KCNH2CYP3A4TRPM8 | |
| SCHEMBL23614085 | 0.71 | TRPV4 (0.46) | TRPV4KCNH2CYP3A4TRPM8 | |
| SCHEMBL23614082 | 0.68 | TRPV4 (0.46) | TRPV4KCNH2CYP3A4 | |
| SCHEMBL23613988 | 0.68 | TRPV4 (0.43) | TRPV4KCNH2CYP3A4TRPM8 | |
| SCHEMBL20007578 | 0.67 | TRPV4 (0.61) | TRPV4KCNH2CYP3A4TRPM8 | |
| SCHEMBL23424715 | 0.64 | TRPV4 (0.51) | TRPV4KCNH2TRPM8 | |
| SCHEMBL23614045 | 0.62 | TRPV4 (0.49) | TRPV4KCNH2CYP3A4TRPM8 | |
| SCHEMBL20007555 | 0.60 | TRPV4 (0.48) | TRPV4KCNH2CYP3A4 | |
| SCHEMBL23614041 | 0.60 | TRPV4 (0.41) | TRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018055524-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2018-03-29 | — | — | WO | disclosed |