Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR2F2 | P24468 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | SLC29A1 | Q99808 | 3/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.45 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12652607 | 0.88 | NR2F2 (0.54) | NR2F2NPC1RAB9ASMN1; SMN2SLC29A1 | |
| SCHEMBL19999967 | 0.84 | SLC29A1 (0.61) | NR2F2SLC29A1CCNA2CDK2CDK5 | |
| SCHEMBL1795030 | 0.80 | SLC29A1 (0.64) | SLC29A1ADORA3 | |
| SCHEMBL12567124 | 0.79 | ABL1 (0.49) | NR2F2NPC1RAB9ASMN1; SMN2SLC29A1 | |
| SCHEMBL12566819 | 0.79 | NPC1 (0.58) | NR2F2NPC1RAB9ASMN1; SMN2SLC29A1 | |
| SCHEMBL12567152 | 0.77 | DNPH1 (0.42) | NR2F2NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL13467551 | 0.76 | NR2F2 (0.58) | NR2F2NPC1RAB9ASMN1; SMN2SLC29A1 | |
| SCHEMBL13467417 | 0.75 | NR2F2 (0.57) | NR2F2NPC1RAB9ASMN1; SMN2SLC29A1 | |
| SCHEMBL13467655 | 0.75 | NPC1 (0.66) | NR2F2NPC1RAB9ASMN1; SMN2SLC29A1 | |
| SCHEMBL13467412 | 0.73 | NR2F2 (0.55) | NR2F2NPC1RAB9ASMN1; SMN2SLC29A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180086785-A1 | SUBSTITUTED PYRROLO[2,3-D]PYRIMIDINES | MILLENNIUM PHARMACEUTICALS, INC. | 2018-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180086785-A1 | SUBSTITUTED PYRROLO[2,3-D]PYRIMIDINES | TYMP, TYMS, PPA1 | NR2F2 2928/4885NPC1 4418/4885RAB9A 2835/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.