Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 4/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 6/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 5/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | BRD9 | Q9H8M2 | 2/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20008703 | 0.66 | CRHR1 (0.35) | RAF1BRAFCRHR1 | |
| SCHEMBL20008141 | 0.61 | BRAF (0.31) | BRAFCRHR1 | |
| SCHEMBL20008772 | 0.60 | BRAF (0.31) | BRAF | |
| SCHEMBL4132041 | 0.58 | MTOR (0.46) | CRHR1CYP3A4PRMT5WDR77 | |
| SCHEMBL10304949 | 0.57 | CYP11B1 (0.58) | CYP11B1CYP11B2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL5702666 | 0.56 | CYP1A1 (0.74) | CYP11B1CYP11B2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL11307533 | 0.56 | CRHR1 (0.46) | CRHR1 | |
| SCHEMBL15296276 | 0.56 | CYP11B1 (0.64) | CYP11B1CYP11B2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL21960161 | 0.55 | CYP11B1 (0.73) | CYP11B1CYP11B2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL24556443 | 0.55 | BRD4 (0.56) | BRD4BRD9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |