Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
| ▸ | CRHR1 | P34998 | 9/20 | 0.36 |
| ▸ | TERT | O14746 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4132572 | 0.86 | MTOR (0.46) | MTORCRHR1PDE5A | |
| SCHEMBL4143420 | 0.80 | CRHR1 (0.42) | MTORCRHR1PDE5AMAPT | |
| SCHEMBL4127685 | 0.79 | PDE5A (0.51) | CRHR1PDE5AMAPT | |
| SCHEMBL4140332 | 0.77 | CRHR1 (0.41) | CRHR1PDE5A | |
| SCHEMBL4130996 | 0.76 | PDE5A (0.41) | MTORCRHR1PDE5A | |
| SCHEMBL4126045 | 0.76 | PDE5A (0.41) | MTORCRHR1PDE5A | |
| SCHEMBL4000244 | 0.76 | PDE5A (0.46) | CRHR1TERTPDE5A | |
| SCHEMBL4115556 | 0.76 | ALDH1A1 (0.41) | MTORCRHR1PDE5AMAPT | |
| SCHEMBL4136240 | 0.75 | CRHR1 (0.39) | MTORCRHR1PDE5AMAPT | |
| SCHEMBL4138719 | 0.74 | PDE5A (0.39) | MTORCRHR1PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071705-A1 | PYRAZOLEPYRIMIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2009-06-11 | — | — | WO | claimed |
| WO-2009071705-A1 | PYRAZOLEPYRIMIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2009-06-11 | — | — | WO | disclosed |