Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 15/20 | 0.58 |
| ▸ | RAF1 | P04049 | 14/20 | 0.58 |
| ▸ | AR | P10275 | 1/20 | 0.54 |
| ▸ | CDK1 | P06493 | 1/20 | 0.52 |
| ▸ | CDK2 | P24941 | 1/20 | 0.52 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.52 |
| ▸ | ATR | Q13535 | 1/20 | 0.50 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.50 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25222662 | 0.87 | BRAF (0.56) | BRAFRAF1CDK1CDK2SMG1 | |
| SCHEMBL20008237 | 0.86 | HRH4 (0.47) | BRAFRAF1LRRK2 | |
| SCHEMBL17850466 | 0.84 | LRRK2 (0.55) | CDK1CDK2SMG1PIK3CDLRRK2 | |
| SCHEMBL19998588 | 0.82 | USP30 (0.54) | BRAFRAF1CDK1CDK2SMG1 | |
| SCHEMBL827848 | 0.81 | PIK3CA (0.58) | CDK1CDK2SMG1LRRK2 | |
| SCHEMBL17430325 | 0.80 | SMG1 (0.47) | BRAFRAF1ARCDK1CDK2 | |
| SCHEMBL20010376 | 0.80 | AR (0.53) | BRAFRAF1ARATRATRIP | |
| SCHEMBL19998635 | 0.78 | LRRK2 (0.48) | BRAFRAF1CDK1CDK2SMG1 | |
| SCHEMBL17430294 | 0.78 | SMG1 (0.47) | BRAFRAF1CDK1CDK2SMG1 | |
| SCHEMBL1443070 | 0.78 | AR (0.48) | BRAFRAF1ARATRATRIP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |