Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.46 |
| ▸ | RAF1 | P04049 | 7/20 | 0.44 |
| ▸ | BRAF | P15056 | 7/20 | 0.44 |
| ▸ | NMT1 | P30419 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.42 |
| ▸ | LYN | P07948 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20008239 | 0.86 | BRAF (0.58) | RAF1BRAFLRRK2 | |
| SCHEMBL11962824 | 0.80 | HRH4 (0.58) | HRH4MAPK14NMT1CNR2PROKR1 | |
| SCHEMBL20008122 | 0.78 | SMN1; SMN2 (0.46) | HRH4RAF1BRAF | |
| SCHEMBL31415288 | 0.78 | GRIN2D (0.57) | HRH4MAPK14CNR2PROKR1 | |
| SCHEMBL4554066 | 0.78 | GRIN2D (0.57) | HRH4MAPK14CNR2PROKR1 | |
| SCHEMBL13575902 | 0.77 | ALDH1A1 (0.43) | — | |
| SCHEMBL1442527 | 0.77 | CNR2 (0.43) | HRH4CNR2 | |
| SCHEMBL20008452 | 0.76 | GALR2 (0.44) | — | |
| SCHEMBL12059087 | 0.74 | GRIN2D (0.57) | HRH4MAPK14PROKR1 | |
| SCHEMBL20008359 | 0.73 | CNR2 (0.42) | CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |