Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 16/20 | 0.43 |
| ▸ | BRAF | P15056 | 16/20 | 0.43 |
| ▸ | PIK3C3 | Q8NEB9 | 3/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20008154 | 0.90 | RAF1 (0.45) | RAF1BRAF | |
| SCHEMBL20008287 | 0.83 | RAF1 (0.44) | RAF1BRAFPIK3C3 | |
| SCHEMBL20009417 | 0.83 | RAF1 (0.42) | RAF1BRAFPIK3C3ROCK2ROCK1 | |
| SCHEMBL20008289 | 0.76 | RAF1 (0.37) | RAF1BRAF | |
| SCHEMBL20008520 | 0.70 | RAF1 (0.71) | RAF1BRAF | |
| SCHEMBL20008778 | 0.70 | RAF1 (0.37) | RAF1BRAFROCK2ROCK1CDC42BPB | |
| SCHEMBL20009415 | 0.68 | RAF1 (0.37) | RAF1BRAF | |
| SCHEMBL20010419 | 0.68 | ALDH1A3 (0.36) | RAF1BRAFROCK2ROCK1CDC42BPB | |
| SCHEMBL20009444 | 0.68 | RAF1 (0.58) | RAF1BRAF | |
| SCHEMBL20008259 | 0.67 | RAF1 (0.38) | RAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |