Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 4/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.41 |
| ▸ | CDC42BPB | Q9Y5S2 | 4/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 7/20 | 0.36 |
| ▸ | BRAF | P15056 | 5/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20009443 | 0.88 | RAF1 (0.37) | ROCK2ROCK1CDC42BPBMAPK14RAF1 | |
| SCHEMBL20008341 | 0.86 | RAF1 (0.38) | ROCK2ROCK1CDC42BPBMAPK14RAF1 | |
| SCHEMBL20008778 | 0.82 | RAF1 (0.37) | ROCK2ROCK1CDC42BPBMAPK14RAF1 | |
| SCHEMBL20009415 | 0.81 | RAF1 (0.37) | MAPK14RAF1BRAF | |
| SCHEMBL20008770 | 0.81 | RAF1 (0.43) | ROCK2ROCK1CDC42BPBMAPK14RAF1 | |
| SCHEMBL20009446 | 0.77 | RAF1 (0.41) | RAF1BRAF | |
| SCHEMBL20008327 | 0.76 | RAF1 (0.59) | RAF1BRAF | |
| SCHEMBL20008475 | 0.74 | RAF1 (0.39) | ROCK2ROCK1CDC42BPBRAF1BRAF | |
| SCHEMBL20008359 | 0.73 | CNR2 (0.42) | MEN1ALDH1A1MAPTKMT2ACNR2 | |
| SCHEMBL20008216 | 0.71 | RAF1 (0.47) | ROCK2ROCK1CDC42BPBRAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |