Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 14/20 | 0.37 |
| ▸ | BRAF | P15056 | 11/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.37 |
| ▸ | CDC42BPB | Q9Y5S2 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.36 |
| ▸ | LYN | P07948 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20008341 | 0.99 | RAF1 (0.38) | RAF1BRAFROCK2ROCK1CDC42BPB | |
| SCHEMBL20008313 | 0.88 | ROCK2 (0.41) | RAF1BRAFROCK2ROCK1CDC42BPB | |
| SCHEMBL20008475 | 0.87 | RAF1 (0.39) | RAF1BRAFROCK2ROCK1CDC42BPB | |
| SCHEMBL20008359 | 0.85 | CNR2 (0.42) | CNR2 | |
| SCHEMBL20008778 | 0.84 | RAF1 (0.37) | RAF1BRAFROCK2ROCK1CDC42BPB | |
| SCHEMBL20009415 | 0.83 | RAF1 (0.37) | RAF1BRAFMAPK14 | |
| SCHEMBL20008770 | 0.83 | RAF1 (0.43) | RAF1BRAFROCK2ROCK1CDC42BPB | |
| SCHEMBL20009446 | 0.79 | RAF1 (0.41) | RAF1BRAF | |
| SCHEMBL20008327 | 0.78 | RAF1 (0.59) | RAF1BRAF | |
| SCHEMBL20008216 | 0.78 | RAF1 (0.47) | RAF1BRAFROCK2ROCK1CDC42BPB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |