SCHEMBL20008355

SCHEMBL20008355

C/C=C\C(=N)c1cc(-c2ccnc(C(C)(C)F)c2)ccc1C

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 1/20 0.32
PDK2 Q15119 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20009217 0.72 RAF1 (0.39)
SCHEMBL25732408 0.68 CYP2D6 (0.40)
SCHEMBL20008773 0.66 CASP1 (0.42)
SCHEMBL31375563 0.61 NOTUM (0.49) IDO1
SCHEMBL15859932 0.61 NOTUM (0.49) IDO1
SCHEMBL31032211 0.61 UHRF1 (0.50)
SCHEMBL16094048 0.61 UHRF1 (0.50)
SCHEMBL23654982 0.59 RAF1 (0.39)
SCHEMBL14063619 0.59
SCHEMBL322475 0.58 SYK (0.52) IDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3299367-A1 BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS Novartis AG (CH) 2018-03-28 EP disclosed