Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 3/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.32 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.32 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | THRB | P10828 | 3/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22889918 | 0.84 | THRB (0.44) | CASP1TSHRALDH1A1CYP3A4PDE10A | |
| SCHEMBL25732408 | 0.81 | CYP2D6 (0.40) | TSHRALDH1A1CYP3A4KDM4ELMNA | |
| SCHEMBL22889739 | 0.81 | CASP1 (0.39) | CASP1TSHRALDH1A1CYP3A4PDE10A | |
| SCHEMBL19061357 | 0.77 | CASP1 (0.41) | CASP1TSHRALDH1A1CYP3A4PDE10A | |
| SCHEMBL26084626 | 0.72 | CASP1 (0.37) | CASP1TSHRALDH1A1CYP3A4PDE10A | |
| SCHEMBL20008147 | 0.70 | CASP1 (0.35) | CASP1TSHRALDH1A1CYP3A4PDE10A | |
| SCHEMBL13004199 | 0.69 | CASP1 (0.48) | CASP1TSHRALDH1A1CYP3A4PDE10A | |
| SCHEMBL25732476 | 0.69 | CYP2D6 (0.41) | TSHRALDH1A1CYP3A4KDM4EMAPT | |
| SCHEMBL25732483 | 0.69 | PRSS1 (0.48) | TSHRALDH1A1PRSS1PRSS2PRSS3 | |
| SCHEMBL14964429 | 0.69 | ALDH1A1 (0.52) | CASP1TSHRALDH1A1CYP3A4PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |