Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.35 |
| ▸ | RAF1 | P04049 | 11/20 | 0.35 |
| ▸ | BRAF | P15056 | 10/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24885810 | 0.65 | RAF1 (0.70) | RAF1BRAF | |
| SCHEMBL20008152 | 0.61 | RAF1 (0.63) | RAF1BRAF | |
| SCHEMBL24319054 | 0.61 | RAF1 (0.63) | RAF1BRAF | |
| SCHEMBL487498 | 0.61 | GAA (0.56) | MAPTALDH1A1GAANPSR1MAPK1 | |
| SCHEMBL24318973 | 0.60 | RAF1 (0.67) | RAF1BRAF | |
| Hydrochloric Acid SCHEMBL28349769 | 0.60 | GAA (0.54) | MAPTALDH1A1GAANPSR1MAPK1 | |
| SCHEMBL21999244 | 0.59 | HTT (0.55) | MAPTALDH1A1MAPK1LMNAHPGD | |
| SCHEMBL17359402 | 0.59 | MAPT (0.43) | MAPTALDH1A1GAAMAPK1LMNA | |
| SCHEMBL108137 | 0.58 | LMNA (0.53) | MAPTALDH1A1MAPK1LMNAPOLB | |
| SCHEMBL14621614 | 0.58 | POLB (0.56) | MAPTALDH1A1TDP1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |