Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | RAF1 | P04049 | 16/20 | 0.47 |
| ▸ | BRAF | P15056 | 16/20 | 0.47 |
| ▸ | TEK | Q02763 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20008594 | 0.75 | RAF1 (0.47) | RAF1BRAF | |
| SCHEMBL20008387 | 0.75 | RAF1 (0.45) | RAF1BRAF | |
| SCHEMBL20008427 | 0.73 | RAF1 (0.48) | RAF1BRAF | |
| SCHEMBL20009199 | 0.73 | RAF1 (0.44) | RAF1BRAF | |
| SCHEMBL20008226 | 0.73 | RAF1 (0.50) | LMNANPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL20008376 | 0.72 | RAF1 (0.42) | RAF1BRAF | |
| SCHEMBL20008430 | 0.70 | RAF1 (0.48) | RAF1BRAF | |
| SCHEMBL26074344 | 0.70 | LMNA (0.74) | LMNANPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL19068912 | 0.70 | BRAF (0.55) | LMNANPC1RAB9ASMN1; SMN2RAF1 | |
| SCHEMBL25996498 | 0.69 | GSK3B (0.47) | RAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |