Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 18/20 | 0.47 |
| ▸ | BRAF | P15056 | 16/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.41 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.41 |
| ▸ | LYN | P07948 | 1/20 | 0.41 |
| ▸ | FASN | P49327 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20008387 | 0.97 | RAF1 (0.45) | RAF1BRAFMAPK14HSPB1LYN | |
| SCHEMBL25996617 | 0.77 | GSK3B (0.48) | RAF1BRAF | |
| SCHEMBL20008415 | 0.75 | LMNA (0.49) | RAF1BRAF | |
| SCHEMBL20008376 | 0.73 | RAF1 (0.42) | RAF1BRAF | |
| SCHEMBL25996593 | 0.69 | RAF1 (0.42) | RAF1BRAF | |
| SCHEMBL25983655 | 0.69 | RAF1 (0.57) | RAF1BRAFMAPK14 | |
| SCHEMBL20008272 | 0.68 | TP53 (0.40) | — | |
| SCHEMBL25702315 | 0.67 | RAF1 (0.57) | RAF1BRAFMAPK14 | |
| SCHEMBL25707412 | 0.67 | ABL1 (0.57) | RAF1BRAF | |
| SCHEMBL25711555 | 0.66 | ABL1 (0.60) | RAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |