Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 19/20 | 0.39 |
| ▸ | BRAF | P15056 | 18/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20010011 | 0.89 | BRAF (0.48) | RAF1BRAFCYP2C9 | |
| SCHEMBL20008376 | 0.76 | RAF1 (0.42) | RAF1BRAF | |
| SCHEMBL20009314 | 0.76 | RAF1 (0.39) | RAF1BRAF | |
| SCHEMBL20009217 | 0.76 | RAF1 (0.39) | RAF1BRAF | |
| SCHEMBL20008263 | 0.75 | BRAF (0.33) | RAF1BRAF | |
| SCHEMBL20009418 | 0.74 | RAF1 (0.43) | RAF1BRAF | |
| SCHEMBL20008367 | 0.73 | RAF1 (0.41) | RAF1BRAFCYP2C9 | |
| SCHEMBL3936862 | 0.69 | BRAF (0.57) | RAF1BRAFCYP2C9 | |
| SCHEMBL20008253 | 0.69 | RAF1 (0.42) | RAF1BRAF | |
| SCHEMBL3944249 | 0.68 | BRAF (0.56) | RAF1BRAFCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |