Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 13/20 | 0.42 |
| ▸ | HTR6 | P50406 | 5/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20009438 | 0.72 | RAF1 (0.52) | RAF1BRAF | |
| SCHEMBL20009429 | 0.66 | KDM4E (0.39) | RAF1BRAF | |
| SCHEMBL20009117 | 0.64 | RAF1 (0.40) | RAF1BRAF | |
| SCHEMBL20008439 | 0.63 | RAF1 (0.67) | RAF1BRAF | |
| SCHEMBL20010381 | 0.61 | RAF1 (0.46) | RAF1BRAF | |
| SCHEMBL20008424 | 0.60 | RAF1 (0.50) | RAF1BRAF | |
| SCHEMBL24766505 | 0.59 | RAF1 (1.00) | RAF1BRAF | |
| SCHEMBL29434122 | 0.59 | RAF1 (1.00) | RAF1BRAF | |
| SCHEMBL23275347 | 0.59 | RAF1 (0.80) | RAF1BRAF | |
| SCHEMBL23275425 | 0.59 | RAF1 (0.80) | RAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |