Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 13/20 | 0.40 |
| ▸ | BRAF | P15056 | 10/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.38 |
| ▸ | LYN | P07948 | 1/20 | 0.38 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20009397 | 0.81 | RAF1 (0.49) | RAF1BRAFALDH1A1CYP1A2HPGD | |
| SCHEMBL20008538 | 0.74 | DRD2 (0.49) | RAF1ALDH1A1CYP1A2HPGDHSD17B10 | |
| SCHEMBL20009100 | 0.74 | NUDT1 (0.37) | ALDH1A1CYP1A2HPGDHSD17B10NUDT1 | |
| SCHEMBL20008778 | 0.71 | RAF1 (0.37) | RAF1BRAFMAPK14HSPB1LYN | |
| SCHEMBL19529392 | 0.71 | RAF1 (0.40) | RAF1BRAFALDH1A1CYP1A2HPGD | |
| SCHEMBL20009443 | 0.71 | RAF1 (0.37) | RAF1BRAFMAPK14HSPB1LYN | |
| SCHEMBL24318983 | 0.71 | RAF1 (0.66) | RAF1BRAF | |
| SCHEMBL20008197 | 0.70 | RAF1 (0.39) | RAF1BRAFMAPT | |
| SCHEMBL20008122 | 0.70 | SMN1; SMN2 (0.46) | RAF1BRAFCYP1A2HSD17B10NUDT1 | |
| SCHEMBL20008460 | 0.70 | RAF1 (0.41) | RAF1BRAFALDH1A1CYP1A2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |