Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 18/20 | 0.43 |
| ▸ | BRAF | P15056 | 17/20 | 0.43 |
| ▸ | LCK | P06239 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | JAK3 | P52333 | 2/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
| ▸ | TEK | Q02763 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20010072 | 0.69 | RAF1 (0.48) | RAF1BRAF | |
| SCHEMBL25984271 | 0.67 | RAF1 (0.58) | RAF1BRAFLCKKDRJAK3 | |
| SCHEMBL13220011 | 0.66 | LCK (0.55) | RAF1BRAFLCKKDRJAK3 | |
| SCHEMBL17523481 | 0.64 | RAF1 (0.77) | RAF1BRAF | |
| SCHEMBL19529238 | 0.63 | RAF1 (0.43) | RAF1BRAF | |
| SCHEMBL25983598 | 0.63 | ABL1 (0.57) | RAF1BRAF | |
| SCHEMBL25702636 | 0.62 | RAF1 (0.57) | RAF1BRAF | |
| SCHEMBL23654063 | 0.60 | RAF1 (0.43) | RAF1BRAF | |
| SCHEMBL25589586 | 0.60 | — | — | |
| SCHEMBL20009106 | 0.59 | MAPT (0.35) | RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |