Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.68 |
| ▸ | RAD52 | P43351 | 3/20 | 0.68 |
| ▸ | ACHE | P22303 | 5/20 | 0.64 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | MITF | O75030 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | TTR | P02766 | 1/20 | 0.62 |
| ▸ | GLA | P06280 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.61 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11934972 | 0.98 | ACHE (0.67) | POLBRAD52ACHERAB9ASLC2A1 | |
| Hydrochloric Acid SCHEMBL8065778 | 0.97 | ACHE (0.65) | POLBRAD52ACHERAB9ASLC2A1 | |
| SCHEMBL7628718 | 0.95 | POLB (0.70) | POLBRAD52ACHERAB9ASLC2A1 | |
| SCHEMBL5578493 | 0.91 | POLB (0.79) | POLBRAD52ACHERAB9ASLC2A1 | |
| SCHEMBL13856923 | 0.89 | POLB (0.77) | POLBRAD52ACHERAB9ASLC2A1 | |
| SCHEMBL6033155 | 0.89 | POLB (0.77) | POLBRAD52ACHERAB9ASLC2A1 | |
| SCHEMBL17423196 | 0.89 | CACNA2D1 (0.69) | POLBRAD52ACHERAB9ASLC2A1 | |
| SCHEMBL8609424 | 0.87 | POLB (0.68) | POLBRAD52ACHERAB9ASLC2A1 | |
| SCHEMBL7869214 | 0.87 | POLB (0.79) | POLBRAD52ACHERAB9ASLC2A1 | |
| SCHEMBL7880366 | 0.87 | POLB (0.78) | POLBRAD52RAB9ASLC2A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023225631-A1 | INTERCALATING SUGAR MOLECULES | XALUD THERAPEUTICS, INC. (US) | 2023-11-23 | — | — | WO | disclosed |
| US-10329258-B2 | CGAS in systemic lupus erythematosus (SLE) | UNIVERSITY OF WASHINGTON (US) | 2019-06-25 | — | — | US | disclosed |
| US-20180086713-A1 | CGAS IN SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) | UNIVERSITY OF WASHINGTON | 2018-03-29 | — | — | US | disclosed |
| US-20180086713-A1 | CGAS IN SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) | UNIVERSITY OF WASHINGTON | 2018-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180086713-A1 | CGAS IN SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) | STING1, IRF3, CGAS | POLB 95/4885RAD52 450/4885ACHE 4872/4885 |
| US-10329258-B2 | CGAS in systemic lupus erythematosus (SLE) | STING1, IRF3, CGAS | POLB 95/4885RAD52 450/4885ACHE 4872/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.