Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 19/20 | 0.57 |
| ▸ | RAF1 | P04049 | 14/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | ARAF | P10398 | 1/20 | 0.48 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.48 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.48 |
| ▸ | AR | P10275 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20010376 | 0.81 | AR (0.53) | BRAFRAF1AR | |
| SCHEMBL17585427 | 0.81 | RAF1 (0.51) | BRAFRAF1PDGFRBARAFDDR1 | |
| SCHEMBL30078044 | 0.78 | BRAF (0.58) | BRAFRAF1PDGFRBARAFDDR1 | |
| SCHEMBL24885817 | 0.78 | BRAF (0.58) | BRAFRAF1PDGFRBARAFDDR1 | |
| SCHEMBL20008239 | 0.77 | BRAF (0.58) | BRAFRAF1AR | |
| SCHEMBL25594444 | 0.76 | BRAF (0.49) | BRAFRAF1PDGFRBARAFDDR1 | |
| SCHEMBL25594442 | 0.76 | RAF1 (0.48) | BRAFRAF1PDGFRBARAFDDR1 | |
| SCHEMBL22488129 | 0.76 | RAF1 (0.58) | BRAFRAF1PDGFRBARAFDDR1 | |
| SCHEMBL20008452 | 0.75 | GALR2 (0.44) | — | |
| SCHEMBL25260758 | 0.74 | BRAF (0.72) | BRAFRAF1PDGFRBARAFDDR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |