Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GALR2 | O43603 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.40 |
| ▸ | GAA | P10253 | 4/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALPL | P05186 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20008122 | 0.82 | SMN1; SMN2 (0.46) | KDM4EL3MBTL1GAAACHETDP1 | |
| SCHEMBL20008237 | 0.76 | HRH4 (0.47) | — | |
| SCHEMBL22488129 | 0.76 | RAF1 (0.58) | KDM4EGAAALDH1A1SMN1; SMN2CRHBP | |
| SCHEMBL20008538 | 0.76 | DRD2 (0.49) | GALR2KDM4EL3MBTL1GAAACHE | |
| SCHEMBL17696413 | 0.76 | SMN1; SMN2 (0.46) | KDM4EL3MBTL1GAAACHEALDH1A1 | |
| SCHEMBL20009412 | 0.75 | RAF1 (0.40) | KDM4EL3MBTL1GAAACHEMAPK1 | |
| SCHEMBL20009114 | 0.75 | BRAF (0.57) | — | |
| SCHEMBL19529392 | 0.75 | RAF1 (0.40) | GALR2KDM4EL3MBTL1GAAACHE | |
| SCHEMBL20009430 | 0.74 | RAF1 (0.49) | KDM4EL3MBTL1GAAACHEMAPK1 | |
| SCHEMBL20008460 | 0.73 | RAF1 (0.41) | KDM4EL3MBTL1GAAACHEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |