Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 17/20 | 0.45 |
| ▸ | BRAF | P15056 | 17/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15730626 | 0.74 | CNR2 (0.64) | KDM4ECNR2 | |
| SCHEMBL20008328 | 0.70 | CNR2 (0.48) | RAF1BRAFKDM4EALDH1A1HPGD | |
| SCHEMBL22562132 | 0.68 | CNR2 (0.46) | KDM4EALDH1A1TDP1CNR2 | |
| SCHEMBL15275375 | 0.64 | GAA (0.50) | KDM4EALDH1A1MAPK1TDP1CNR2 | |
| SCHEMBL15730742 | 0.63 | MKNK1 (0.50) | ALDH1A1 | |
| SCHEMBL23299891 | 0.63 | KMT2A (0.50) | RAF1BRAFKDM4EALDH1A1HPGD | |
| SCHEMBL14861520 | 0.62 | PRKD3 (0.45) | RAF1BRAFKDM4EALDH1A1NPSR1 | |
| SCHEMBL2294733 | 0.62 | GRIN2B (0.55) | KDM4EALDH1A1 | |
| SCHEMBL30937159 | 0.62 | GRIN2B (0.55) | KDM4EALDH1A1 | |
| SCHEMBL15730143 | 0.62 | PKM (0.57) | KDM4EALDH1A1NPSR1USP2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |