Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.48 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 7/20 | 0.39 |
| ▸ | BRAF | P15056 | 7/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20008486 | 0.79 | CNR2 (0.45) | CNR2SMN1; SMN2GAAALDH1A1RAF1 | |
| SCHEMBL20008499 | 0.72 | RAF1 (0.51) | ALDH1A1RAF1BRAF | |
| SCHEMBL25594314 | 0.71 | RAF1 (0.63) | CRHBPCRHR2KMT2ARAF1BRAF | |
| SCHEMBL20008296 | 0.71 | SMARCA2 (0.40) | CNR2SMN1; SMN2RAF1BRAF | |
| SCHEMBL20009409 | 0.70 | RAF1 (0.45) | CNR2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL20008469 | 0.70 | CNR2 (0.38) | CNR2RAF1BRAF | |
| SCHEMBL20008890 | 0.69 | RAF1 (0.49) | RAF1BRAF | |
| SCHEMBL20008122 | 0.69 | SMN1; SMN2 (0.46) | CRHBPCRHR2SMN1; SMN2L3MBTL1KDM4E | |
| SCHEMBL20008452 | 0.67 | GALR2 (0.44) | CRHBPCRHR2SMN1; SMN2L3MBTL1KDM4E | |
| SCHEMBL82447 | 0.66 | CNR2 (0.62) | CNR2ALDH1A1NPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |