Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 9/20 | 0.45 |
| ▸ | BRAF | P15056 | 5/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | LCK | P06239 | 7/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.41 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.40 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.40 |
| ▸ | KCNE1 | P15382 | 2/20 | 0.40 |
| ▸ | KCNQ1 | P51787 | 2/20 | 0.40 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.40 |
| ▸ | BLK | P51451 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20009576 | 0.74 | RAF1 (0.40) | BRAFRAF1 | |
| SCHEMBL20008505 | 0.69 | RAF1 (0.47) | BRAFRAF1 | |
| SCHEMBL19623099 | 0.69 | LMNA (0.68) | — | |
| SCHEMBL4434874 | 0.66 | KCNQ3 (0.65) | BTKBRAFLCKMAPK14KDR | |
| SCHEMBL16036513 | 0.66 | KCNQ3 (0.65) | BTKBRAFCYP2C9LCKMAPK14 | |
| SCHEMBL24275085 | 0.66 | KCNQ3 (0.65) | BTKBRAFCYP2C9LCKMAPK14 | |
| SCHEMBL20009609 | 0.65 | BTK (0.32) | BTKBRAFCYP2C9 | |
| SCHEMBL21877180 | 0.65 | KCNQ3 (0.63) | BTKBRAFCYP2C9LCKMAPK14 | |
| SCHEMBL26075509 | 0.65 | KCNQ3 (0.63) | BTKBRAFCYP2C9LCKMAPK14 | |
| SCHEMBL19073411 | 0.64 | BRAF (0.53) | BRAFLCKMAPK14KDRCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |