Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.32 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20009423 | 0.72 | MEN1 (0.36) | MEN1KMT2AGAASMN1; SMN2POLB | |
| SCHEMBL27875965 | 0.71 | NFE2L2 (0.50) | MEN1KMT2ASMN1; SMN2POLBNFE2L2 | |
| SCHEMBL24000666 | 0.69 | KMT2A (0.51) | MEN1KMT2AGAASMN1; SMN2POLB | |
| SCHEMBL25732408 | 0.67 | CYP2D6 (0.40) | MEN1KMT2AGAASMN1; SMN2NFE2L2 | |
| SCHEMBL18432619 | 0.65 | MEN1 (0.35) | MEN1KMT2AGAASMN1; SMN2POLB | |
| SCHEMBL11024692 | 0.64 | NFE2L2 (0.54) | MEN1KMT2ASMN1; SMN2POLBNFE2L2 | |
| SCHEMBL11024683 | 0.64 | NFE2L2 (0.54) | MEN1KMT2ASMN1; SMN2POLBNFE2L2 | |
| SCHEMBL25797292 | 0.64 | MEN1 (0.34) | MEN1KMT2ASMN1; SMN2NFE2L2TSHR | |
| SCHEMBL20009422 | 0.63 | MEN1 (0.33) | MEN1KMT2ASMN1; SMN2NFE2L2HSD17B10 | |
| SCHEMBL24000797 | 0.63 | MEN1 (0.39) | MEN1KMT2AGAASMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |