Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20009422 | 0.85 | MEN1 (0.33) | MEN1KMT2ANFE2L2SMN1; SMN2ALOX5 | |
| SCHEMBL20008531 | 0.84 | — | — | |
| SCHEMBL23624332 | 0.76 | MEN1 (0.39) | MEN1KMT2ANFE2L2SMN1; SMN2POLB | |
| SCHEMBL27875965 | 0.75 | NFE2L2 (0.50) | MEN1KMT2ANFE2L2SMN1; SMN2POLB | |
| SCHEMBL20008548 | 0.74 | TP53 (0.31) | TDP1 | |
| SCHEMBL20009603 | 0.72 | MEN1 (0.36) | MEN1KMT2ANFE2L2SMN1; SMN2POLB | |
| SCHEMBL20008147 | 0.71 | CASP1 (0.35) | TSHR | |
| SCHEMBL20008186 | 0.70 | — | — | |
| SCHEMBL11024683 | 0.69 | NFE2L2 (0.54) | MEN1KMT2ANFE2L2SMN1; SMN2POLB | |
| SCHEMBL11024692 | 0.69 | NFE2L2 (0.54) | MEN1KMT2ANFE2L2SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |