Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 6/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 4/20 | 0.39 |
| ▸ | PLG | P00747 | 2/20 | 0.39 |
| ▸ | PLAU | P00749 | 2/20 | 0.39 |
| ▸ | C1S | P09871 | 1/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
| ▸ | KLK1 | P06870 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 2/20 | 0.39 |
| ▸ | F12 | P00748 | 2/20 | 0.38 |
| ▸ | F7 | P08709 | 1/20 | 0.38 |
| ▸ | F3 | P13726 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL19995251 | 0.98 | PRSS1 (0.42) | LOXL2PRSS1PRSS2PRSS3IDO1 | |
| SCHEMBL2996754 | 0.79 | PARP1 (0.48) | LOXL2F7F3 | |
| SCHEMBL20270479 | 0.79 | CYP1A2 (0.46) | LOXL2PRSS1PRSS2PRSS3F2 | |
| Hydrochloric Acid SCHEMBL29533953 | 0.77 | CYP1A2 (0.45) | PRSS1PRSS2PRSS3F2PLG | |
| Hydrochloric Acid SCHEMBL9792756 | 0.77 | PRSS1 (0.50) | PRSS1PRSS2PRSS3F2PLG | |
| SCHEMBL1159737 | 0.77 | F12 (0.44) | LOXL2PRSS1PRSS2PRSS3F2 | |
| SCHEMBL31656123 | 0.76 | TAS1R3 (0.39) | LOXL2IDO1 | |
| SCHEMBL3554899 | 0.75 | PRSS1 (0.50) | PRSS1PRSS2PRSS3F2PLG | |
| SCHEMBL2435961 | 0.75 | RECQL (0.44) | LOXL2PRSS1PRSS2PRSS3IDO1 | |
| SCHEMBL29027023 | 0.75 | LOXL2 (0.49) | LOXL2IDO1KLKB1F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3515903-B1 | PREPARATION AND USES OF PYRIMIDINONE DERIVATIVES | CANCER RESEARCH TECH LTD (GB) | 2020-10-21 | — | — | EP | disclosed |
| WO-2018055402-A1 | PREPARATION AND USES OF PYRIMIDINONE DERIVATIVES | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2018-03-29 | — | — | WO | disclosed |