Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | WNT3A | P56704 | 7/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 7/20 | 0.41 |
| ▸ | GRIA1 | P42261 | 3/20 | 0.40 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.40 |
| ▸ | GRIA3 | P42263 | 3/20 | 0.40 |
| ▸ | GRIA4 | P48058 | 3/20 | 0.40 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19996050 | 0.85 | HPGD (0.41) | HPGDALDH1A1HSD17B10MAPTALOX15 | |
| SCHEMBL20012186 | 0.85 | HPGD (0.41) | HPGDALDH1A1HSD17B10MAPTALOX15 | |
| SCHEMBL20012418 | 0.85 | HPGD (0.41) | HPGDALDH1A1HSD17B10MAPTALOX15 | |
| SCHEMBL20011964 | 0.85 | HPGD (0.41) | HPGDALDH1A1HSD17B10MAPTALOX15 | |
| SCHEMBL20012245 | 0.81 | TNKS2 (0.44) | HPGDALDH1A1HSD17B10MAPTALOX15 | |
| SCHEMBL20012277 | 0.81 | ALDH1A1 (0.43) | HPGDALDH1A1HSD17B10MAPTALOX15 | |
| SCHEMBL20011826 | 0.78 | WNT3A (0.39) | HPGDALDH1A1HSD17B10MAPTALOX15 | |
| SCHEMBL20154080 | 0.74 | DAO (0.33) | — | |
| SCHEMBL20011967 | 0.74 | GSK3B (0.51) | HPGDALDH1A1HSD17B10MAPTALOX15 | |
| SCHEMBL19995232 | 0.71 | GRIA1 (0.40) | HPGDALDH1A1HSD17B10MAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3515903-B1 | PREPARATION AND USES OF PYRIMIDINONE DERIVATIVES | CANCER RESEARCH TECH LTD (GB) | 2020-10-21 | — | — | EP | disclosed |
| WO-2018055402-A1 | PREPARATION AND USES OF PYRIMIDINONE DERIVATIVES | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2018-03-29 | — | — | WO | disclosed |